The Thomas Nelson House in Yorktown, Virginia, served multiple purposes throughout its history. Originally built around 1725, the house was used as a hospital during the American Civil War. However, its historical significance dates back to 1781 when it functioned as Lord Cornwallis' headquarters during the decisive siege of Yorktown, marking a significant turning point in the American Revolutionary War. The house is associated with Thomas Nelson Jr., a signer of the Declaration of Independence, who lived there for much of his life. Today, the house stands as a testament to both the nation's founding and its Civil War era history.